The Human Fertilisation and Embryology Authority announced Monday it has
granted a research application to a team led by scientist Kathy Niakan
to try to understand the genes that human embryos need to develop
successfully.
Scientists say gene-editing techniques could one day lead to treatments
for conditions like HIV, which causes AIDS, and inherited diseases like
muscular dystrophy and sickle cell disease.
Niakan, of the Francis Crick Institute, plans to use gene editing to analyze the first week of an embryo's growth.
This research will "enhance our understanding of (in vitro
fertilization) success rates, by looking at the very earliest stage of
human development," said Paul Nurse, director of the Francis Crick
Institute.
Peter Braude, an emeritus professor of obstetrics and gynecology at
King's College London, said the mechanisms being investigated by Niakan
and colleagues "are crucial in ensuring healthy, normal development and
implantation" and could help doctors understand how to improve in vitro
fertilization rates and prevent miscarriages.
Braude is not connected to Niakan's research.
Last year, Chinese researchers made the first attempt at modifying genes
in human embryos. Their laboratory experiment didn't work — the embryos
weren't viable — but raised the prospect of altering genes to repair
the genes of future generations.
The gene-editing technique was developed partly in the U.S. and
scientists there have experimented with the method in animals and in
human cells in the laboratory. Gene editing has not been used for any
kinds of patient therapies just yet.
Around the world, laws and guidelines vary widely about what kind of
research is allowed on embryos, since it could change the genes of
future generations. In the U.S., the National Institutes of Health won't fund this kind of research but private funding is allowed.
Critics warn that tweaking the genetic code this way could eventually
produce a slippery slope that eventually leads to so-called "designer
babies," where parents seek taller, stronger or smarter children with
specific physical characteristics.
"This is the first step on a path that scientists have carefully mapped
out towards the legalization of (genetically modified) babies," said David King,
of anti-gene manipulation group Human Genetics Alert. He spoke last
month when the British fertility regulator held its meeting to decide
whether to grant the gene-editing license.
At an international meeting in Washington
last year, scientists agreed that efforts to research the possibility
of gene editing should continue, despite the ethical and legal problems
the technique raises.
Last year, British lawmakers voted to allow scientists to create babies
from the DNA of three people to prevent children from inheriting
potentially fatal diseases from their mothers. In doing so, it became
the first country in the world to allow genetically modified embryos to
be transferred into women.
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